Tofaxen 5 mg Tablet

Generic Name: Tofacitinib
Brand Name: Tofaxen
Strength: 5 mg
Form: Oral Tablet
Pack Size: Commonly 60 tablets per bottle (varies)
Manufacturer: Everest Pharmaceuticals
Distributed by: NP Molecule

Indications:

Tofaxen (Tofacitinib) is indicated for the treatment of:

• Rheumatoid arthritis (RA) – moderate to severe, in adults who have had inadequate response to methotrexate

• Psoriatic arthritis (PsA) – in adults with inadequate response to nonbiologic DMARDs

• Ulcerative colitis (UC) – moderate to severe active cases in adults

• Juvenile idiopathic arthritis (JIA) – in pediatric patients aged 2 years and older (dose adjusted)

Pharmacology:

Tofacitinib is a Janus kinase (JAK) inhibitor.
It works by blocking JAK1 and JAK3 enzymes involved in the inflammatory process, thereby reducing the activity of immune cells responsible for chronic inflammation and autoimmune disorders.

Dosage & Administration:

• Usual adult dose: 5 mg twice daily (or 11 mg once daily in XR formulations for some indications)

• Taken with or without food

• Dose adjustment may be needed in renal/hepatic impairment or with CYP3A4 inhibitors

Drug Interactions:

• Use caution with CYP3A4 inhibitors/inducers

• Avoid use with other potent immunosuppressants (e.g., biologics or cyclosporine)

Contraindications:

• Hypersensitivity to Tofacitinib or any component

• Active serious infections (e.g., TB, sepsis)

Side Effects:

• Common: Headache, upper respiratory infections, diarrhea, high blood pressure

• Serious: Serious infections, blood clots, cancer risk, elevated liver enzymes

Pregnancy & Lactation:

• Use during pregnancy only if clearly needed

• Breastfeeding should be avoided during and for at least 18 hours after the last dose

Precautions & Warnings:

• Regularly monitor CBC, liver function, lipids, and signs of infection

• Screen for TB and hepatitis B/C before starting

• Risk of serious heart-related events, malignancies, and thromboembolism

Overdose Effects:

• May lead to increased risk of infections or liver toxicity

• Provide supportive care as needed

Therapeutic Class:

• JAK Inhibitor / Immunomodulatory Agent / DMARD (Disease-Modifying Anti-Rheumatic Drug)

Storage Conditions:

• Store below 30°C

• Protect from moisture and light

• Keep out of reach of children