Tirzix 7.5 mg

Generic Name: Tirzepatide
Brand: Tirzix
Strength: 7.5 mg
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form: Prefilled Pen / Subcutaneous Injection

Description:

Tirzix 7.5 mg is a once-weekly subcutaneous injection of Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It is used to improve glycemic control in adults with type 2 diabetes mellitus. Tirzix offers a dual-action approach, enhancing insulin secretion and reducing glucagon levels, while also slowing gastric emptying and promoting weight loss.

Indications:

• As an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes Mellitus

• Can be used alone or in combination with other antidiabetic agents like metformin, SGLT2 inhibitors, or insulin

Mechanism of Action:

Tirzepatide activates both GIP and GLP-1 receptors, leading to:

• Enhanced insulin secretion in a glucose-dependent manner

• Suppressed glucagon secretion

• Improved insulin sensitivity

• Delayed gastric emptying and appetite suppression

This dual receptor activity makes it more effective in glycemic control and weight management than traditional GLP-1 receptor agonists alone.

Dosage & Administration:

• Initial dose: 2.5 mg once weekly

• Titrate up to 7.5 mg weekly after at least 4 weeks to improve glycemic control

• Administer subcutaneously in the abdomen, thigh, or upper arm

• Can be taken at any time of day, with or without meals

Side Effects:

• Common: Nausea, vomiting, diarrhea, decreased appetite, constipation

• Serious (rare): Pancreatitis, hypoglycemia (when used with insulin or sulfonylureas), kidney impairment, allergic reactions

Contraindications:

• Personal or family history of medullary thyroid carcinoma (MTC)

• Multiple endocrine neoplasia syndrome type 2 (MEN 2)

• Hypersensitivity to Tirzepatide or formulation components

Pregnancy & Lactation:

• Not recommended during pregnancy unless clearly necessary

• Use with caution during lactation; consult physician

Therapeutic Class:

Incretin Mimetics / Dual GIP and GLP-1 Receptor Agonist

Storage Conditions:

• Store in a refrigerator at 2°C to 8°C

• Do not freeze

• Protect from light