Quizar 17.7 mg Tablet

Generic Name: Abiraterone Acetate
Brand Name: Quizar
Strength: 17.7 mg
Form: Film-coated Tablet
Pack Size: Commonly 120 tablets per bottle
Manufacturer: Everest Pharmaceuticals
Distributed by: NP Molecule

Indications:

Quizar (Abiraterone Acetate) is indicated for the treatment of:

• Metastatic castration-resistant prostate cancer (mCRPC)

• Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
  Used in combination with prednisone or prednisolone.

Pharmacology:

Abiraterone is a CYP17 inhibitor, which blocks androgen production at all sources (testes, adrenal glands, and tumor tissue).
This suppression of testosterone helps slow the growth and spread of androgen-dependent prostate cancer.

Dosage & Administration:

• Recommended dose: 1,000 mg once daily, taken as multiple tablets depending on strength (Quizar 17.7 mg allows flexible dosing).

• Taken on an empty stomach, at least 1 hour before or 2 hours after eating.

• Must be administered with prednisone (5 mg twice daily) to reduce the risk of corticosteroid-related side effects.

Drug Interactions:

• Strong CYP3A4 inducers/inhibitors may affect drug levels.

• Avoid drugs that prolong QT interval.

Contraindications:

• Known hypersensitivity to Abiraterone or any component.

• Contraindicated in pregnant women due to potential fetal harm.

Side Effects:

• Common: Fatigue, joint swelling, hypertension, low potassium, fluid retention.

• Serious: Hepatotoxicity, cardiac disorders.

Pregnancy & Lactation:

• Contraindicated in pregnancy and women of childbearing potential.

• Men must use effective contraception during and after treatment.

Precautions & Warnings:

• Monitor liver function and blood pressure regularly.

• Risk of adrenal insufficiency—must be taken with corticosteroids.

Overdose Effects:

• May increase risk of side effects like hypokalemia or liver toxicity.

• Supportive care recommended.

Therapeutic Class:

• Hormonal Therapy / CYP17 Inhibitor

Storage Conditions:

• Store below 30°C.

• Protect from moisture and light.

• Keep out of reach of children.