💊 Ponaxen 15 mg Tablets

(Ponatinib Hydrochloride INN)

A Potent Oral Therapy for Resistant Leukemia

🔍 Product Summary:

• Brand Name: Ponaxen

• Generic Name: Ponatinib Hydrochloride INN

• Strength: 15 mg

• Form: Film-coated tablets

• Packaging: Bottle of 30 tablets

• Manufacturer: Everest Pharmaceuticals Ltd.

• Marketed by: NP Molecule

🧬 What is Ponaxen (Ponatinib)?

Ponaxen contains Ponatinib, a powerful third-generation tyrosine kinase inhibitor (TKI) used in the treatment of specific types of leukemia. It is uniquely designed to target and inhibit BCR-ABL fusion protein, including those with the T315I mutation — a mutation resistant to most other TKIs.

✅ Indications:

Ponaxen is indicated for the treatment of:

✔️ Chronic Myeloid Leukemia (CML) – Chronic, Accelerated, or Blast Phase
✔️ Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
✔️ Particularly effective in patients with the T315I mutation or who are resistant or intolerant to previous TKIs

💊 Dosage & Administration:

• Recommended starting dose: 15 mg orally once daily

• Can be taken with or without food

• Dose adjustments may be required based on individual response and side effects

• Regular monitoring of blood counts, liver function, and cardiovascular health is advised

⚙️ Mechanism of Action:

Ponatinib works by inhibiting BCR-ABL kinase, including mutated forms such as T315I, and other kinases involved in cancer progression. It effectively blocks cancer cell signaling, proliferation, and survival.

⚠️ Potential Side Effects:

Common adverse effects may include:

• Hypertension

• Rash

• Abdominal pain

• Fatigue

• Nausea

• Increased liver enzymes

• Vascular occlusive events (e.g., blood clots)

🚨 Black Box Warning: Ponatinib carries risks of arterial occlusion, venous thrombosis, and hepatotoxicity. Use under strict medical supervision.

🧊 Storage:

• Store below 30°C in a dry place

• Keep away from moisture and direct sunlight

• Keep out of reach of children

🏥 Manufactured by:

Everest Pharmaceuticals Ltd. – WHO-GMP Compliant, Quality-Certified

📦 Exclusively Marketed by:
🔬 NP Molecule – Oncology Expertise You Can Trust

📍 Sector-14, Uttara, Dhaka – 1230
📞 +8801844288466
📧 npmolecule23@gmail.com
🌐 www.npmoleculeoncology.com
📱 Scan the QR code for inquiries or bulk orders

🎯 Ponaxen – Targeting Leukemia with Precision

Fighting Resistance. Redefining Outcomes.