Pazorest 200 mg Tablet

Generic Name: Pazopanib
Brand Name: Pazorest
Strength: 200 mg
Form: Film-coated Tablet
Pack Size: 30 Tablets (commonly)
Manufacturer: Everest Pharmaceuticals
Distributed by: NP Molecule

Indications:

Pazorest (Pazopanib) is indicated for the treatment of:

• Advanced Renal Cell Carcinoma (RCC)

• Advanced Soft Tissue Sarcoma (STS) in patients who have received prior chemotherapy

• May also be used off-label for certain other solid tumors under oncologist supervision

Pharmacology:

Pazopanib is a tyrosine kinase inhibitor (TKI) that targets multiple receptors involved in tumor growth and angiogenesis, including:

• Vascular Endothelial Growth Factor Receptors (VEGFR)

• Platelet-Derived Growth Factor Receptors (PDGFR)

• Fibroblast Growth Factor Receptors (FGFR)
  This inhibition blocks tumor blood vessel formation and limits cancer progression.

Dosage & Administration:

• The typical dose is 800 mg once daily, taken on an empty stomach (at least 1 hour before or 2 hours after a meal).

• Dosage may be adjusted based on patient tolerance, liver function, and side effects.

Drug Interactions:

• Avoid use with strong CYP3A4 inhibitors or inducers.

• Proton pump inhibitors and antacids may reduce absorption.

Contraindications:

• Known hypersensitivity to Pazopanib.

• Severe hepatic impairment.

Side Effects:

• Common: Hypertension, fatigue, diarrhea, nausea, hair color changes.

• Serious: Hepatotoxicity, cardiac dysfunction, hemorrhagic events, thromboembolism.

Pregnancy & Lactation:

• Not recommended during pregnancy; may cause fetal harm.

• Avoid breastfeeding during and for 2 weeks after the last dose.

Precautions & Warnings:

• Monitor liver function tests before and during treatment.

• Blood pressure should be controlled and regularly monitored.

• Risk of QT prolongation—monitor ECGs in at-risk patients.

Overdose Effects:

• May result in severe hypertension and organ toxicities.

• Supportive care and monitoring are essential.

Therapeutic Class:

• Targeted Therapy

• Tyrosine Kinase Inhibitor (TKI)

Storage Conditions:

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.