🟩 Nilonix 150 mg

Generic Name: Nilotinib
Brand Name: Nilonix
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form & Strength: Capsule, 150 mg
Therapeutic Class: Tyrosine Kinase Inhibitor (TKI) | Anticancer Agent

📌 Indications:

Nilonix (Nilotinib) is indicated for the treatment of:

• Philadelphia chromosome–positive Chronic Myeloid Leukemia (Ph+ CML) in the chronic phase and accelerated phase, both in newly diagnosed adults and in those resistant or intolerant to prior therapy, including imatinib.

💊 Pharmacology:

Nilotinib is a selective BCR-ABL tyrosine kinase inhibitor that blocks the ATP-binding site of the BCR-ABL oncoprotein, which is the abnormal tyrosine kinase responsible for uncontrolled leukemic cell proliferation in CML.

• More potent than imatinib in inhibiting BCR-ABL.

• Also inhibits other kinases such as PDGFR and KIT.

• Reduces leukemic cell proliferation and induces apoptosis.

💉 Dosage & Administration:

• Recommended dose: 300 mg twice daily (two 150 mg capsules) taken approximately 12 hours apart.

• Take on an empty stomach — at least 2 hours after a meal and avoid food for at least 1 hour after taking the dose.

• Swallow capsules whole with water.

• Dose adjustments may be required in case of side effects or certain co-morbidities.

⚠️ Precautions & Warnings:

• QT prolongation risk — ECG monitoring before and during therapy.

• Monitor electrolytes (potassium, magnesium) regularly.

• May cause myelosuppression — regular blood counts needed.

• Use caution in patients with hepatic impairment.

• Avoid strong CYP3A4 inhibitors or inducers.

❌ Contraindications:

• Hypersensitivity to Nilotinib or any excipient.

• Uncorrected hypokalemia or hypomagnesemia.

• Long QT syndrome.

🤰 Pregnancy & Lactation:

• May cause fetal harm — use effective contraception during treatment.

• Avoid breastfeeding during therapy and for at least 2 weeks after the last dose.

⚕️ Side Effects:

Common:

• Rash, itching

• Nausea, vomiting

• Fatigue, headache

• Constipation or diarrhea

• Myalgia, arthralgia

Serious:

• QT prolongation, sudden cardiac death (rare)

• Severe myelosuppression

• Hepatic dysfunction

• Pancreatitis

🧊 Storage Conditions:

• Store below 30°C, in a cool, dry place.

• Protect from light and moisture.

• Keep out of reach of children.