Liposem 2 mg Tablet

Generic Name: Saroglitazar Magnesium
Brand Name: Liposem
Strength: 2 mg
Form: Oral Tablet
Pack Size: 3 x 10 Tablets (30 tablets per box)
Manufacturer: Noted on packaging (likely Everest or its affiliate)
Distributed by: NP Molecule

Indications:

Liposem (Saroglitazar Magnesium) is indicated for the management of:

• Dyslipidemia, particularly diabetic dyslipidemia

• Hypertriglyceridemia in type 2 diabetic patients not controlled with statin therapy alone

• Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) (off-label use in some regions)

Pharmacology:

Saroglitazar is a dual PPAR (Peroxisome Proliferator-Activated Receptor) α/γ agonist.

• PPAR-α activation helps reduce triglycerides and LDL cholesterol

• PPAR-γ activation improves insulin sensitivity and glucose metabolism
  Together, it addresses both lipid abnormalities and insulin resistance, offering a comprehensive metabolic benefit in patients with type 2 diabetes and associated lipid disorders.

Dosage & Administration:

• Standard dosage: 2 mg once daily, taken orally

• May be taken with or without food

• Dosage adjustments are generally not needed in mild to moderate hepatic/renal impairment

Drug Interactions:

• Minimal CYP450 interaction; low risk of drug-drug interactions

• Can be used safely with statins, metformin, and other antidiabetic agents

Contraindications:

• Hypersensitivity to Saroglitazar or any tablet components

• Severe hepatic impairment

• History of bladder cancer (precautionary)

Side Effects:

• Common: Gastric discomfort, flatulence, mild elevation in liver enzymes

• Rare: Myopathy (especially with statin use), edema

Pregnancy & Lactation:

• Not recommended during pregnancy unless clearly necessary

• Avoid use during lactation unless benefits outweigh risks

Precautions & Warnings:

• Monitor liver function periodically

• Use cautiously in patients with a history of edema or heart failure

• Regular lipid profile testing is recommended

Overdose Effects:

• No major toxicity reported with overdose

• Symptomatic and supportive treatment is recommended

Therapeutic Class:

• Dual PPAR α/γ Agonist / Anti-Diabetic & Lipid-Lowering Agent

Storage Conditions:

• Store below 30°C in a dry place

• Protect from direct sunlight and moisture

• Keep out of reach of children