Eudaxen 50 mg Tablet

Generic Name:Diazoxide
Brand Name: Eudaxen
Strength: 50 mg
Formulation: Oral Tablets
Pack Size: 100 Tablets
Manufacturer: Everest Pharmaceuticals
Distributed by: NP Molecule

Indications:

Eudaxen (Diazoxide) is primarily indicated for:

• Management of Hypoglycemia due to hyperinsulinism (such as in insulinoma or congenital hyperinsulinism).

• Hypertensive Crisis (in specific acute cases as an emergency antihypertensive agent, though less commonly used now for this purpose).

Pharmacology:

Diazoxide is a potassium channel opener that acts by:

• Inhibiting insulin release from the pancreas, making it effective for hypoglycemia due to excessive insulin production.

• Relaxing vascular smooth muscles, producing vasodilation and reducing blood pressure in emergency cases.

It does not lower blood sugar directly, but instead limits the insulin-mediated glucose drop.

Dosage & Administration:

• For hypoglycemia: Initial dose and titration should be based on body weight, age, and clinical response.

• Oral tablets are usually taken 2–3 times daily.

• Regular blood glucose monitoring is essential.

Interaction:

• May interact with antihypertensive agents, sulfonylureas, and diuretics.

• Concomitant use with drugs that raise blood sugar may amplify hyperglycemic effects.

Contraindications:

• Known hypersensitivity to Diazoxide.

• Use with caution in patients with congestive heart failure or impaired kidney function.

Side Effects:

• Hyperglycemia

• Edema or fluid retention

• Hypotension (rare)

• Increased body hair (hypertrichosis) in children

Pregnancy & Lactation:

• Use in pregnancy only if clearly necessary.

• Should be used with caution in breastfeeding mothers, as excretion in milk is unknown.

Precautions & Warnings:

• Monitor blood sugar and electrolytes regularly.

• Caution in renal and cardiac patients due to fluid retention.

• Not for routine hypertension management—used only in specific emergency scenarios.

Overdose Effects:

• Can lead to excessive hyperglycemia, hypotension, and fluid retention.

• Symptomatic treatment and supportive care are recommended.

Therapeutic Class:

• Antihypoglycemic Agent

• Potassium Channel Opener

• Emergency Antihypertensive (rare use)

Storage Conditions:

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.