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💊 Therapeutic Category
Antineoplastic agent / Anticancer drug Fibroblast growth factor receptor (FGFR) inhibitor 🩸 Indications and Uses
Treatment of adults with locally advanced or metastatic urothelial carcinoma (bladder cancer) with susceptible FGFR2 or FGFR3 genetic alterations, confirmed by an approved diagnostic test. Usually used after progression following at least one prior line of platinum-containing chemotherapy. ⚙️ Mechanism of Action
Erdafitinib is an oral FGFR kinase inhibitor. It works by blocking the activity of FGFR2 and FGFR3, which are involved in tumor cell proliferation and survival. By inhibiting these pathways, it slows or stops the growth of cancer cells with FGFR mutations or fusions. 📈 Pharmacokinetics
Absorption: Rapid, peak concentration ~2–4 hours Bioavailability: ~40–50% Distribution: Extensive, protein binding ~99% Metabolism: Primarily by CYP2C9, CYP3A4 enzymes Elimination: Half-life ~50 hours; excreted mostly in feces 💊 Dosage and Administration
Typical starting dose: 8 mg once daily Dose adjustments based on phosphate levels and patient tolerance Administer with or without food Regular monitoring of serum phosphate is required ⚠️ Warnings and Precautions
Hyperphosphatemia (high blood phosphate) Eye disorders: Central serous retinopathy / retinal pigment epithelial detachment → requires ophthalmologic monitoring Hepatic and renal impairment: Use with caution Fetal toxicity: Avoid use in pregnancy; use effective contraception ❗ Adverse Reactions (Side Effects)
Hyperphosphatemia Stomatitis (mouth sores) Fatigue Diarrhea Dry mouth, dry skin Nail changes Eye toxicity (blurred vision, dry eyes) Elevated creatinine, liver enzymes 🔄 Drug Interactions
Metabolized by CYP2C9 and CYP3A4 → avoid strong inducers or inhibitors May interact with phosphate-lowering therapies 👥 Use in Specific Populations
Pregnancy / Lactation: Avoid; can harm fetus Pediatric Use: Not established Geriatric Use: No specific adjustments, but monitor carefully 📦 Storage and Packaging
Store below 30°C Protect from moisture and light Keep in original packaging until use 📌 Summary Table
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