Enzamide® 40 mg (Enzalutamide INN)

Advanced Androgen Receptor Inhibitor for Prostate Cancer

💊 Pharmacology:

Enzalutamide is a second-generation androgen receptor (AR) inhibitor that works by:

• Blocking androgen binding to the receptor
• Inhibiting AR nuclear translocation
• Preventing DNA binding and transcription activity

This leads to suppression of androgen-driven tumor growth in prostate cancer.

📌 Indications:

Enzamide® 40 mg is indicated for:

• Metastatic Castration-Resistant Prostate Cancer (mCRPC)
• Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)
• Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Used alone or in combination with androgen deprivation therapy (ADT).

💉 Dosage & Administration:

• Recommended dose: 160 mg once daily (typically 4 tablets of 40 mg)
• Taken orally with or without food
• Swallow tablets whole with water
• Continue treatment as long as clinical benefit is observed

⚠️ Use only under oncologist supervision.

⚠️ Precautions & Warnings:

• Risk of seizures (rare but serious)
• Monitor blood pressure regularly
• Increased risk of fatigue, falls, and fractures
• Caution in patients with neurological disorders
• Potential drug interactions (CYP enzyme involvement)

❌ Contraindications:

• Hypersensitivity to Enzalutamide or any formulation component
• Not indicated for use in women

🤰 Pregnancy & Lactation:

• Contraindicated in women, especially during pregnancy
• May cause fetal harm
• Male patients should use effective contraception during treatment

⚕️ Side Effects:

Common side effects include:

• Fatigue
• Hot flashes
• Hypertension
• Headache
• Dizziness
• Weakness

Serious but less common:

• Seizures
• Cardiovascular complications
• Falls and fractures

🧊 Storage Conditions:

• Store below 30°C
• Keep in a cool and dry place
• Protect from light and moisture
• Keep out of reach of children