Elopag 25 mg Tablet

Generic Name: Eltrombopag
Brand: Everest
Strength: 25 mg
Pack Size: 14 Tablets
Manufacturer: Everest Pharmaceuticals
Distributed by: NP Molecule

Indications:

Elopag 25 mg is used for the treatment of:

• Chronic Immune Thrombocytopenia (ITP) in adults and children unresponsive to corticosteroids, immunoglobulins, or splenectomy.

• Thrombocytopenia in chronic Hepatitis C patients to allow initiation and maintenance of interferon-based therapy.

• Severe Aplastic Anemia (SAA) in patients who are refractory to other treatments or as first-line therapy in some cases.

Pharmacology:

Eltrombopag is a thrombopoietin receptor agonist that stimulates the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, leading to increased platelet production. It acts specifically on the thrombopoietin (TPO) receptor (c-Mpl receptor).

Dosage & Administration:

• Starting dose typically 25 mg once daily, adjusted based on platelet response and patient profile.

• Must be taken on an empty stomach (1 hour before or 2 hours after a meal), avoiding calcium-rich foods.

• Dosage varies depending on disease indication and liver function.

Interaction:

• Reduced absorption with calcium, antacids, dairy products, and mineral supplements.

• Monitor liver function if used with hepatotoxic drugs.

Contraindications:

• Known hypersensitivity to Eltrombopag or any tablet components.

Side Effects:

• Common: Nausea, headache, diarrhea, fatigue.

• Serious: Elevated liver enzymes, thromboembolic events, bone marrow fibrosis (rare).

Pregnancy & Lactation:

• Use only if clearly needed during pregnancy.

• Unknown if excreted in breast milk—caution advised.

Precautions & Warnings:

• Regular platelet monitoring is essential.

• Monitor liver function tests regularly.

• Risk of excessive platelet increase and thrombosis.

Overdose Effects:

• May lead to elevated platelet counts and associated clotting risks.

• Discontinue and monitor closely.

Therapeutic Class:

• Thrombopoietin Receptor Agonist

• Hematology / Oncology Supportive Therapy

Storage Conditions:

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.