🟩 Dasanix 50 mg

Generic Name: Dasatinib
Brand Name: Dasanix
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form & Strength: Film-coated tablet, 50 mg
Therapeutic Class: Tyrosine Kinase Inhibitor (TKI) | Anticancer Agent

📌 Indications:

Dasanix (Dasatinib) is indicated for the treatment of:

• Chronic Myeloid Leukemia (CML) in chronic, accelerated, or blast phase

• Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)

• CML or Ph+ ALL in patients resistant or intolerant to prior therapy including imatinib

💊 Pharmacology:

Dasatinib is a multi-targeted tyrosine kinase inhibitor that blocks:

• BCR-ABL (responsible for CML and Ph+ ALL)

• SRC family kinases

• c-KIT, EPHA2, and PDGFRβ

By inhibiting these kinases, Dasanix interrupts cancer cell signaling, preventing proliferation and inducing apoptosis. It works against many imatinib-resistant BCR-ABL mutations.

💉 Dosage & Administration:

• CML (chronic phase): 100 mg orally once daily

• CML (accelerated/blast phase) or Ph+ ALL: 140 mg orally once daily

• Tablets should be swallowed whole, with or without food

• Avoid grapefruit juice

• Dose adjustments may be necessary for toxicity

⚠️ Precautions & Warnings:

• Risk of myelosuppression – monitor blood counts regularly

• Fluid retention (pleural effusion, pericardial effusion, edema) may occur

• QT prolongation – ECG monitoring recommended in at-risk patients

• Use with caution in patients with heart disease or liver impairment

• Avoid concomitant use with strong CYP3A4 inhibitors or inducers

❌ Contraindications:

• Known hypersensitivity to dasatinib or any component of the formulation

🤰 Pregnancy & Lactation:

• May cause fetal harm – not recommended during pregnancy

• Avoid breastfeeding during treatment and for at least 2 weeks after last dose

⚕️ Side Effects:

Common:

• Headache

• Nausea, vomiting, diarrhea

• Fatigue

• Myalgia, muscle cramps

• Skin rash

• Anemia, neutropenia, thrombocytopenia

Serious:

• Severe myelosuppression

• Pleural/pericardial effusion

• Pulmonary arterial hypertension (PAH)

• Gastrointestinal bleeding

• QT prolongation

🧊 Storage Conditions:

• Store below 30°C, in a dry place

• Keep away from light and moisture

• Keep out of reach of children