🟩 Bariganix 180 mg

Generic Name: Ibrutinib
Brand Name: Bariganix
Strength: 180 mg
Dosage Form: Capsule
Manufacturer: Beacon Pharmaceuticals Ltd.
Category: Targeted Therapy | Oncology | Bruton's Tyrosine Kinase (BTK) Inhibitor

📌 Indications:

Bariganix (Ibrutinib) is indicated for the treatment of various B-cell malignancies, including:

• Chronic Lymphocytic Leukemia (CLL)

• Mantle Cell Lymphoma (MCL) (after at least one prior therapy)

• Waldenström’s Macroglobulinemia (WM)

• Marginal Zone Lymphoma (MZL) (after at least one anti-CD20-based therapy)

• Chronic Graft-Versus-Host Disease (cGVHD) after failure of one or more systemic therapies

💊 Pharmacology:

Bariganix (Ibrutinib) is a first-in-class Bruton's tyrosine kinase (BTK) inhibitor that irreversibly binds to BTK. BTK plays a crucial role in B-cell receptor signaling and survival of malignant B-cells. Inhibiting BTK leads to reduced proliferation and increased apoptosis of abnormal B-cells, providing a highly targeted anti-cancer effect.

💉 Dosage & Administration:

• CLL/SLL/WM: 420 mg orally once daily

• MCL/MZL: 560 mg orally once daily

• cGVHD: 420 mg orally once daily

• Swallow whole with water. Do not open, break, or chew the capsule.

• Dose may vary based on treatment plan or patient profile.

⚠️ Precautions & Warnings:

• Bleeding risks – avoid use with anticoagulants/antiplatelets

• Infections – monitor for bacterial, viral, or fungal infections

• Atrial fibrillation and hypertension – monitor cardiac function

• Tumor lysis syndrome – assess risk prior to initiation

• Hepatotoxicity – monitor liver function tests

• Cytopenias – regular blood count monitoring is essential

❌ Contraindications:

• Known hypersensitivity to Ibrutinib or any excipients

• Concurrent use with strong CYP3A inhibitors or inducers

🤰 Pregnancy & Lactation:

• Not recommended during pregnancy; may cause fetal harm

• Avoid breastfeeding during treatment and for one week after the last dose

⚕️ Side Effects:

Common:

• Diarrhea

• Fatigue

• Nausea

• Bruising

• Muscle and joint pain

Serious:

• Atrial fibrillation

• Major hemorrhage

• Infections (pneumonia, sepsis)

• Cytopenias (neutropenia, anemia, thrombocytopenia)

🧊 Storage:

• Store below 30°C in a dry place

• Protect from moisture and direct sunlight

• Keep out of reach of children