🟩 Baricinix 4 mg
Generic Name: Baricitinib
Brand Name: Baricinix
Strength: 4 mg
Dosage Form: Film-coated Tablet
Manufacturer: Beacon Pharmaceuticals Ltd.
📌 Indication:
Baricinix 4 mg is indicated for the treatment of:
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Moderate to severe rheumatoid arthritis (RA) in adults who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs).
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COVID-19: Emergency use in hospitalized patients requiring supplemental oxygen or mechanical ventilation.
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Alopecia Areata (in some countries) – under investigation/approval.
💊 Pharmacology:
Baricitinib is a Janus kinase (JAK) inhibitor, specifically inhibiting JAK1 and JAK2 enzymes. These enzymes play a key role in the signaling pathways that regulate immune response and inflammation. By blocking these pathways, Baricinix reduces inflammation, swelling, and joint damage associated with autoimmune disorders.
🔄 Dosage & Administration:
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Rheumatoid Arthritis: 4 mg once daily.
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COVID-19 (Hospitalized Patients): 4 mg once daily for 14 days or until discharge.
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Dosage adjustments may be required in renal impairment or infections.
⚠️ Warnings & Precautions:
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Increased risk of serious infections, including tuberculosis.
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Monitor for lymphoma and other malignancies.
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Risk of thrombosis, including deep vein thrombosis (DVT) and pulmonary embolism.
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Regular monitoring of blood counts, liver enzymes, and lipid levels is required.
❌ Contraindications:
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Active serious infections (e.g., TB, sepsis).
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Severe hepatic impairment.
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Known hypersensitivity to Baricitinib.
🤰 Pregnancy & Lactation:
⚕️ Side Effects:
Common:
Serious:
💉 Therapeutic Class:
🧊 Storage Conditions:
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Store at below 30°C in a dry place.
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Protect from light and moisture.
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Keep out of reach of children.
