🟩 Apalunix 60 mg

Generic Name: Apalutamide
Brand Name: Apalunix
Strength: 60 mg (commonly)
Formulation: Oral Tablet
Manufacturer: Beacon Pharmaceuticals Ltd.

📌 Indications:

Apalunix (Apalutamide) is indicated for the treatment of:

• Non-metastatic castration-resistant prostate cancer (nmCRPC)

• Metastatic castration-sensitive prostate cancer (mCSPC)

Apalunix is used in combination with gonadotropin-releasing hormone (GnRH) analog therapy or following surgical castration.

💊 Pharmacology:

Apalutamide is a non-steroidal androgen receptor inhibitor. It binds directly to the ligand-binding domain of the androgen receptor (AR), inhibiting its activity. By blocking AR-mediated signaling pathways, it prevents cancer cell growth and proliferation in androgen-sensitive prostate cancer.

Compared to earlier AR inhibitors, Apalutamide shows stronger receptor binding and reduced stimulation of mutant AR, offering a more targeted and effective approach in delaying disease progression.

🔄 Dosage & Administration:

• Recommended Dose: 240 mg (usually four 60 mg tablets) taken orally once daily.

• Can be taken with or without food.

• Administer with ongoing androgen deprivation therapy (ADT).

❌ Contraindications:

• Hypersensitivity to Apalutamide or any ingredient in the formulation.

• Use in women (especially during pregnancy) is contraindicated due to teratogenicity.

⚠️ Warnings & Precautions:

• Seizure Risk: Avoid activities where a sudden loss of consciousness could cause harm.

• Fractures & Falls: Increased risk in older patients; monitor bone health.

• Hypothyroidism: Monitor TSH levels during treatment.

• Cardiovascular Disorders: Use with caution in patients with heart conditions.

• Hepatic Impairment: Dose adjustment may be required.

🤰 Use in Pregnancy & Lactation:

• Not indicated for use in women.

• May cause fetal harm if administered during pregnancy.

• Not recommended during breastfeeding.

⚕️ Side Effects:

Common Adverse Effects:

• Fatigue

• Rash

• Hypertension

• Diarrhea

• Nausea

• Weight loss

• Joint pain

• Falls & fractures

• Hypothyroidism

• Hot flashes

Serious Side Effects:

• Seizures

• Severe rash or hypersensitivity

• Hepatotoxicity

• Cardiovascular events

💉 Therapeutic Class:

• Hormonal Therapy / Anti-Androgen Therapy

• Androgen Receptor Inhibitor

🧊 Storage Conditions:

• Store at below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.