🟦 Alecnix 150 mg

Generic Name: Alectinib
Brand Name: Alecnix
Strength: 150 mg
Formulation: Oral Capsule
Manufacturer: Beacon Pharmaceuticals Ltd.

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📌 Indications:

Alecnix (Alectinib) 150 mg is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It is used both as:

• First-line therapy, and

• Subsequent-line therapy in patients who have progressed on or are intolerant to Crizotinib.

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💊 Pharmacology:

Alectinib is a selective ALK inhibitor that blocks the ALK fusion gene responsible for driving cancer cell growth in ALK-positive NSCLC. It inhibits tumor proliferation and survival by disrupting ALK-mediated signaling pathways. Alectinib is also active in the central nervous system (CNS) and is effective in treating brain metastases—a common complication in ALK-positive NSCLC.

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🔄 Dosage & Administration:

• Recommended Dose: 600 mg (i.e., 4 capsules of 150 mg) twice daily with food.

• Continue until disease progression or unacceptable toxicity.

• Dose adjustments may be required based on adverse reactions.

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❗ Contraindications:

• Hypersensitivity to Alectinib or any excipient in the formulation.

• Caution in patients with hepatic or renal impairment.

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⚠️ Warnings & Precautions:

• Hepatotoxicity: Monitor ALT, AST, bilirubin levels regularly.

• Bradycardia: Monitor heart rate and ECG in symptomatic patients.

• Interstitial Lung Disease/Pneumonitis: Discontinue if suspected.

• Myalgia & CPK Elevation: Monitor muscle pain and creatine kinase levels.

• Photosensitivity: Advise sun protection during treatment.

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🤰 Use in Pregnancy & Lactation:

• Pregnancy: May cause fetal harm. Not recommended.

• Lactation: Breastfeeding should be avoided during treatment and for at least 1 week after the final dose.

• Contraception: Women of reproductive potential should use effective contraception during treatment and for at least 1 week after the last dose.

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⚕️ Side Effects:

Common Side Effects:

• Constipation

• Fatigue

• Muscle pain

• Peripheral edema

• Anemia

• Rash

• Increased liver enzymes

Serious Adverse Effects:

• Interstitial lung disease

• Hepatic injury

• Bradycardia

• Severe myopathy

• Renal impairment

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💉 Therapeutic Class:

• Targeted Cancer Therapy

• ALK Tyrosine Kinase Inhibitor

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🧊 Storage Conditions:

• Store below 30°C, away from moisture and direct sunlight.

• Keep out of reach of children.

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