Abemaxen 150 mg (Abemaciclib INN) 

Abemaxen (Abemaciclib 150 mg) is indicated for the treatment of:

• Hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer

• Used in combination with endocrine therapy (aromatase inhibitors or fulvestrant)

• May also be used as monotherapy in patients with disease progression following endocrine therapy and chemotherapy

It is prescribed under the guidance of an experienced oncologist.

💊 Pharmacology:

Abemaciclib is a selective cyclin-dependent kinase (CDK) 4 and CDK 6 inhibitor.

Mechanism of action:

• Inhibits CDK4/6 activity

• Prevents phosphorylation of retinoblastoma (Rb) protein

• Causes cell cycle arrest at the G1 phase

• Reduces proliferation of cancer cells in HR-positive breast cancer

Compared to other CDK inhibitors, Abemaciclib has continuous dosing and strong activity against tumor growth.

💉 Dosage & Administration:

• Recommended dose: 150 mg twice daily

• May be taken with or without food

• Tablets should be swallowed whole with water

• Continue treatment until disease progression or unacceptable toxicity

• Dose adjustments may be required based on tolerability and adverse effects

Treatment must be initiated and supervised by an oncology specialist.

⚠️ Precautions & Warnings:

• Monitor complete blood count (CBC) regularly

• Monitor liver function tests (ALT, AST, bilirubin)

• Risk of diarrhea, which may require early management

• Increased risk of infections due to neutropenia

• Use caution in patients with hepatic impairment

• Avoid strong CYP3A inhibitors or inducers

❌ Contraindications:

• Hypersensitivity to Abemaciclib or any component of the formulation

• Severe hepatic impairment

• Uncontrolled infections

🤰 Pregnancy & Lactation:

• Pregnancy: Contraindicated; may cause fetal harm

• Lactation: Breastfeeding should be avoided during treatment and for at least 3 weeks after the last dose

• Effective contraception is required for women of childbearing potential

⚕️ Side Effects:

Common side effects include:

• Diarrhea

• Fatigue

• Nausea and vomiting

• Decreased appetite

• Neutropenia

• Anemia

• Elevated liver enzymes

Serious but less common:

• Severe infections

• Venous thromboembolism

• Hepatotoxicity

• Interstitial lung disease (rare)

🧊 Storage Conditions:

• Store below 25°C

• Keep in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children